2026-10-13 https://api.researchdata.se/oai-pmh

oai:researchdata.se:2023-222/1 2026-03-19 subject:ssif:1 subject:ssif:106 subject:ssif:10604 subject:ssif:10609 subject:ssif:10610 subject:ssif:30202 subject:ssif:30112 subject:ssif:301 subject:ssif:302 subject:ssif:3 principal:slug:karolinska-institutet

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.48723/tt0e-eq82 10X single-cell RNA sequencing of hematopoietic stem and progenitor cells from a dual SF3B1-mutant MDS-RS patient and a healthy donor 10X single-cell RNA sequencing of hematopoietic stem and progenitor cells from a dual SF3B1-mutant MDS-RS patient and a healthy donor https://orcid.org/0000-0002-0493-5394 https://orcid.org/0000-0002-7839-3743 Natural Sciences Naturvetenskap Biological Sciences Biologi Cell Biology Cellbiologi Genetics and Genomics Genetik och genomik Bioinformatics and Computational Biology Bioinformatik och beräkningsbiologi Hematology Hematologi Basic Cancer Research Basal cancerforskning This dataset consists of 10X single-cell RNA sequencing data of bone marrow cells (CD34+ stem cells) obtained from two clinical visits of a dual SF3B1-mutant MDS-RS patient (Patient 1 in the associated publication: visits at 31 months post-diagnosis, with dominant SF3B1 N626D; and at 118 months post-diagnosis, with dominant SF3B1 K666N) and one healthy bone marrow donor. The objective of this data collection was to assess how the hematopoietic stem and progenitor cell compartment of this patient differed over time and as a result of changes in clonal frequency. The dataset is appoximately 80.9 GB and has filetypes txt, rds and fastq. Syftet med denna datainsamling var att bedöma hur det hematopoetiska stam- och progenitorcellsutrymmet hos en patient skiljde sig över tiden och som ett resultat av förändringar i klonal frekvens. Se den engelska beskrivningen för mer information. info:eu-repo/semantics/restrictedAccess https://creativecommons.org/licenses/by-nc-nd/4.0/ Karolinska Institutet Karolinska Institutet 2024-04-18T13:21:03.97973Z eng