2026-10-14 https://api.researchdata.se/oai-pmh

oai:researchdata.se:2025-152/1 2026-02-27 subject:ssif:30203 subject:ssif:30209 subject:ssif:30223 subject:ssif:302 subject:ssif:3 principal:slug:karolinska-institutet

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.48723/v39q-2169 Data for: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)" Data för: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)" https://orcid.org/0000-0003-4602-4297 Biotechnology Bioteknik Cancer and Oncology Cancer och onkologi Infectious Medicine Infektionsmedicin Clinical Laboratory Medicine Klinisk laboratoriemedicin Human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC) is suggested to arise in tonsillar crypts. They also constitute a rare exception in the literature of carcinoma development, as carcinoma in situ (CIS) is not a recognized entity and dysplastic stages are not evident. Here we used spatial transcriptomics (10x Visium) on HPV-associated TSCC, cervical and HPV-independent oral cancer cases on morphological normal, dysplastic and invasive epithelium. Files included were: - histpopathological annotations - spatial data/images as a zip-file - filtered_feautre_bc_matrix.h5-file per sample Humant papillomvirus (HPV) associerade tonsillkarcinom anses ha sitt ursprung från tonsillkryptor och utgör ett undantag i cancerutvecklingsmodellerna, eftersom de inte anses företrädas av in-situförändringar. Här använder vi oss av spatialtranskriptomik (10X Visium) på HPV-associerade tonsill- cervix och HPV-oberoende orala karcinom och undersöker morfologiskt normala, dysplastiska och invasiva epitelceller. Filer som inkluderas i analysen är: - histopatologiska annoteringar - spatialdata/bilder i zip-format - filtered_feautre_bc_matrix.h5 per prov info:eu-repo/semantics/restrictedAccess Karolinska Institutet Karolinska Institutet 2025-06-09T14:57:02.331072Z eng