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        <identifier>oai:researchdata.se:2025-97/1</identifier>
        <datestamp>2026-06-11</datestamp>
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          <dc:identifier>https://doi.org/10.48723/f4v5-m008</dc:identifier>
          <dc:title xml:lang="en">Computational pathology annotation enhances the resolution and interpretation of breast cancer spatial transcriptomics data</dc:title>
          <dc:title xml:lang="sv">Computational pathology annotation enhances the resolution and interpretation of breast cancer spatial transcriptomics data</dc:title>
          <dc:creator>https://orcid.org/0000-0003-2246-4896</dc:creator>
          <dc:creator>https://orcid.org/0000-0002-4098-3246</dc:creator>
          <dc:creator>https://orcid.org/0000-0002-0972-4633</dc:creator>
          <dc:creator>https://orcid.org/0000-0001-9919-4471</dc:creator>
          <dc:creator>https://orcid.org/0000-0002-5525-4724</dc:creator>
          <dc:creator>https://orcid.org/0000-0001-5090-4161</dc:creator>
          <dc:creator>https://orcid.org/0000-0003-3109-5551</dc:creator>
          <dc:creator>https://orcid.org/0000-0001-5298-7861</dc:creator>
          <dc:creator>https://orcid.org/0000-0003-2195-2978</dc:creator>
          <dc:creator>https://orcid.org/0009-0007-2807-4668</dc:creator>
          <dc:creator>https://orcid.org/0000-0001-5598-0243</dc:creator>
          <dc:creator>https://orcid.org/0009-0008-5893-1373</dc:creator>
          <dc:creator>https://orcid.org/0000-0001-5819-458X</dc:creator>
          <dc:creator>https://orcid.org/0000-0002-4552-0240</dc:creator>
          <dc:creator>https://orcid.org/0000-0003-4313-1601</dc:creator>
          <dc:creator>https://orcid.org/0000-0002-3214-9075</dc:creator>
          <dc:creator>https://orcid.org/0000-0002-6500-8527</dc:creator>
          <dc:subject xml:lang="en">Cancer and Oncology</dc:subject>
          <dc:subject xml:lang="sv">Cancer och onkologi</dc:subject>
          <dc:subject xml:lang="en">Medical Life Sciences</dc:subject>
          <dc:subject xml:lang="sv">Medicinska biovetenskaper</dc:subject>
          <dc:subject xml:lang="en">Medical Bioinformatics and Systems Biology</dc:subject>
          <dc:subject xml:lang="sv">Medicinsk bioinformatik och systembiologi</dc:subject>
          <dc:description xml:lang="en">The samples in the dataset are connected to a study focusing on studying breast cancer intratumoral heterogeneity using spatial transcriptomic data and computational pathology. The dataset contains 14 samples from 3 patients (one triple negative breast cancer and two HER2-positive breast cancer). Multiple regions of the tumor were collected for analysis. Each sample is one tumor region from one of the patients.

Libraries for spatial transcriptomics were prepared using Visium spatial gene expression kits (10x genomics). Sequencing was performed using the Illumina NovaSeq 6000 platform at the National Genomics Infrastructure, SciLifeLab in Solna, Sweden. 

The dataset contains 28 fastq files, compressed with GNUzip (gzip), from paired-end RNA sequencing (10X Visium spatial transcriptomics). The meta data is described in SND_metadata.xlsx file. The md5sum.txt file is provided for validation of data integrity. The total size of the dataset is approximately 300 GB.</dc:description>
          <dc:description xml:lang="sv">Proverna i datamängden är kopplade till en studie som fokuserar på att studera intratumoral heterogenitet i bröstcancer med användning av rumsliga transkriptomiska data och beräkningspatologi. Datauppsättningen innehåller 14 prover från 3 patienter (en trippelnegativ bröstcancer och två HER2-positiva bröstcancer). Flera regioner av tumören samlades in för analys. Varje prov är en tumörregion från en av patienterna.

Bibliotek för rumslig transkriptomik framställdes med användning av Visium rumsliga genuttryckskit (10x genomik). Sekvensering utfördes med hjälp av Illumina NovaSeq 6000-plattformen vid National Genomics Infrastructure, SciLifeLab i Solna, Sverige.

Datasetet består av 28 filer i fastq-format, komprimerade med GNUzip (gzip), från paired-end-RNA-sekvensering (10X Visium spatial transcriptomics). Metadata är beskrivna i filen SND_metadata.xlsx. För validering av dataintegritet finns filen md5sum.txt. Datasetets totala storlek är ungefär 300 GB.</dc:description>
          <dc:rights>info:eu-repo/semantics/restrictedAccess</dc:rights>
          <dc:coverage>SE</dc:coverage>
          <dc:publisher xml:lang="en">Karolinska Institutet</dc:publisher>
          <dc:publisher xml:lang="sv">Karolinska Institutet</dc:publisher>
          <dc:date>2025-09-01T09:42:18.464625Z</dc:date>
          <dc:language>eng</dc:language>
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