2026-10-14 https://api.researchdata.se/oai-pmh

oai:researchdata.se:2026-29/1 2026-09-04 subject:ssif:10605 subject:ssif:10610 subject:ssif:30107 subject:ssif:30108 subject:ssif:30202 subject:ssif:30203 subject:ssif:106 subject:ssif:301 subject:ssif:302 subject:ssif:1 subject:ssif:3 principal:slug:karolinska-institutet

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.48723/ep36-6r74 Data for: Single-cell sequencing reveals transcriptional and immunogenetic diversity in stereotyped chronic lymphocytic leukemia Data för: Single-cell sequencing reveals transcriptional and immunogenetic diversity in stereotyped chronic lymphocytic leukemia https://orcid.org/0000-0002-0211-8788 0009-0007-0755-3643 0009-0004-7839-2929 Sameer A. Parikh Karla Plevova 0000-0002-8389-8367 Anastasia Chatzidimitriou Sarka Pospisilova Neil E. Kay Kostas Stamatopoulos 0000-0001-7506-084X Specific diseases, disorders and medical conditions Specifika sjukdomar, störningar och medicinska tillstånd Immunology Immunologi Bioinformatics and Computational Biology Bioinformatik och beräkningsbiologi Medical Genetics and Genomics Medicinsk genetik och genomik Cell and Molecular Biology Cell- och molekylärbiologi Hematology Hematologi Cancer and Oncology Cancer och onkologi The dataset contains raw single-cell sequencing data generated from a study of 13 individuals with chronic lymphocytic leukemia (CLL). The patients belong to three biologically defined patient subgroups in which leukemic B cells express highly similar (often near-identical) B-cell receptor immunoglobulin sequences, namely stereotyped subsets #1, #2, and #4. The data were generated using single-cell RNA sequencing (10x Genomics Single Cell 5′ Gene Expression and V(D)J) and include information on gene expression, B-cell receptor repertoires, and T-cell receptor repertoires. The dataset consists of raw sequencing files (FASTQ format) and associated technical metadata. The dataset consists of 138 FASTQ files with a total size of approximately 511 GB. Datasetet innehåller rådata från enkelcellssekvensering genererade i en studie av 13 individer med kronisk lymfatisk leukemi (KLL). Patienterna tillhör tre biologiskt definierade patientsubgrupper där leukemiska B-celler uttrycker mycket likartade (ofta nära identiska) B-cellsreceptor immunoglobulinsekvenser, nämligen stereotypa subset #1, #2 och #4. Data har genererats med enkelcells-RNA-sekvensering (10x Genomics Single Cell 5′ Gene Expression and V(D)J) och omfattar information om genuttryck, B-cellsreceptorrepertoarer samt T-cellsreceptorrepertoarer. Datasetet består av råa sekvenseringsfiler (FASTQ-format) och tillhörande teknisk metadata. Datasetet består av 138 FASTQ-filer. Datasetets totala storlek är ca 511 GB. info:eu-repo/semantics/restrictedAccess Karolinska Institutet Karolinska Institutet 2026-09-04T07:33:37.883461Z eng