2026-10-14 https://api.researchdata.se/oai-pmh

oai:researchdata.se:doi-10-17044-scilifelab-21904578/0 2023-06-03 subject:ssif:3 subject:ssif:10609 subject:ssif:106 subject:ssif:1 principal:slug:lund-university

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.17044/SCILIFELAB.21904578 Mutational Signature Contribution of Matched Primary and Recurrent Breast Tumors https://orcid.org/0000-0002-4845-1084 Medical and Health Sciences Medicin och hälsovetenskap Genetics and Genomics Genetik och genomik Mutational signature contribution table reports COSMIC mutational signatures (v2; https://cancer.sanger.ac.uk/signatures/signatures_v2/) for matched primary and locally recurrent tumors (n = 27 + 27). "SUBSTITUTION.TABLE" contains the number of nucleotide substitutions (type by sample). "MUT.SIG.contribution" reorts the fractional contribution of all 30 COSMIC signatures in each samples. "MUT.SIG.contrib.DELTA" reports pair-wise contribution difference (DELTA = contribution.recurrence - contribution.primary) for paired samples. This dataset was used for Figure 2 in the following manuscript: "Proteogenomics decodes the evolution of human ipsilateral breast cancer". De Marchi T, Pyl PT, Sjöström M, Reinsbach SE, DiLorenzo S, Nystedt B, Tran L, Pekar G, Wärnberg F, Fredriksson I, Malmström P, Fernö M, Malmström L, Malmström J, Nimèus E. accepted for publication https://creativecommons.org/licenses/by/4.0/ Lund University Lunds universitet 2023-01-25T00:00:00Z