2026-10-14 https://api.researchdata.se/oai-pmh

oai:researchdata.se:doi-10-17044-scilifelab-23715648/0 2025-10-07 subject:ssif:3 subject:ssif:30203 subject:ssif:302 principal:slug:lund-university

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.17044/SCILIFELAB.23715648 Single cell sequencing data from: The AML cellular state space unveils NPM1 immune evasion subtypes with distinct clinical outcomes https://orcid.org/0000-0001-8703-1173 Thoas Fioretos Medical and Health Sciences Medicin och hälsovetenskap Cancer and Oncology Cancer och onkologi This dataset contains 10X single cell 3' RNA sequencing gene expression data from from 38 AML-samples from the subtypes NPM1 (n=12), AML-MR (n=11), TP53 (n=7), CBFB::MYH11 (n=3), RUNX1::RUNX1T1 (n=3), AML without class defining mutations (n=1), and AML meeting the criteria for two subtypes (n=1). In addition, reference samples from normal bone marrow mononuclear cells (n=5) and CD34 sorted cells (n=3) are included. The single cell libraries were constructed from viably frozen cells from bone marrow (n=29+8) or peripheral blood (n=9) using the Chromium Single Cell 3' Library & Gel Bead Kit v3 (10X genomics) and sequenced on a Novaseq 6000 or NextSeq 500. Data is available in h5 format for each sample, with raw count output from Cellranger, or as a processed Seurat object with scaled expression data, dimension reductions, and metadata. https://creativecommons.org/licenses/by-nc-nd/4.0/ Lund University Lunds universitet 2025-10-07T00:00:00Z