2026-10-12 https://api.researchdata.se/oai-pmh

oai:researchdata.se:doi-10-17044-scilifelab-24260710/0 2023-11-24 subject:ssif:3 subject:ssif:106 subject:ssif:1 principal:slug:lund-university

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.17044/SCILIFELAB.24260710 Activating mutations remodeled the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A-rearranged acute leukemia associated with immune evasion Qirui Zhang https://orcid.org/0000-0002-5341-4472 https://orcid.org/0000-0002-9235-1953 Helena Sturesson Anders Castor Hanne V. Marquart Birgitte Lausen Axel Hyrenius Wittsten Anna Hagström Andersson Medical and Health Sciences Medicin och hälsovetenskap Biological Sciences Biologi This dataset includes ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) of five infants with acute lymphoblastic leukemia. All patients had an underlying rearrangement of the KMT2A genes, either KMT2A::MLLT1 (n=1), KMT2A::AFF1 (n=3), or KMT2A::MLLT10 (n=1). Three patients also had activating mutations of NRAS G13D and/or KRAS G12D. The median age of the cohort was 2 months 7 days. Diagnostic sample from bone marrow underwent the ATAC-seq library preparation and sequenced on the NextSeq 500 platform (Illumina, San Diego, CA, USA). info:eu-repo/semantics/restrictedAccess Lund University Lunds universitet 2023-11-24T00:00:00Z