2026-10-13 https://api.researchdata.se/oai-pmh

oai:researchdata.se:doi-10-17044-scilifelab-31385350/0 2026-05-04 subject:ssif:3 subject:ssif:21003 subject:ssif:210 subject:ssif:2 subject:ssif:30101 subject:ssif:301 principal:slug:uppsala-university

info:eu-repo/semantics/other http://purl.org/dc/dcmitype/Dataset https://doi.org/10.17044/SCILIFELAB.31385350 Flash Nanoprecipitation for Co-Delivery of Diagnostic Magnetic Nanoparticles and Anti-Inflammatory Drugs in Polymeric Nanocarriers https://orcid.org/0000-0002-6366-7836 Alex Eric Weber Shaquib Rahman Ansari https://orcid.org/0000-0001-9405-8278 Qianying Chen https://orcid.org/0009-0001-5504-9720 https://orcid.org/0000-0003-1694-6987 Alexandra Teleki Medical and Health Sciences Medicin och hälsovetenskap Nanotechnology for Materials Science Nanoteknisk materialvetenskap Pharmaceutical Sciences Farmaceutiska vetenskaper Chronic inflammatory diseases may benefit from nanocarrier platforms that co-deliver hydrophobic anti-inflammatory drugs and imaging agents. Here, we report polymeric theranostic nanocarrier dispersions produced by flash nanoprecipitation (FNP) that encapsulate flame-made manganese-doped superparamagnetic iron oxide nanoparticles (SPIONs; Mn0.25Fe2.75O4) together with T‑5224, a model small-molecule inhibitor of the c‑Fos/c‑Jun activator protein‑1 (AP‑1) complex. We first mapped key formulation and process parameters governing dispersion properties, including PLA–PEG molecular weight, total solute concentration, solvent-to-antisolvent ratio, and SPION:polymer mass ratio. These studies identified conditions yielding smaller, narrowly distributed dispersions. Using the optimized formulation, T‑5224/SPION nanocarrier dispersions were purified by magnetic separation and exhibited hydrodynamic diameters https://creativecommons.org/licenses/by/4.0/ Uppsala University Uppsala universitet 2026-03-05T00:00:00Z